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POSTECH team turns the ribosome into a six-input logic gate, expanding what living cells can compute

Researchers in Pohang have wired six natural signals into a protein-building switch, the latest move in a years-long effort to make cells behave like programmable circuits.

Desk note: Monexus frames this as a methodological shift inside synthetic biology rather than as a one-off breakthrough. The wire coverage of ribosome-based circuits has tended to lead with quotable numbers ("six inputs"); this piece instead locates the result inside the longer move from DNA-binding regulators to RNA- and ribosome-level logic, and names the two industrial pressures, biomanufacturing and therapeutic cell engineering, that make the direction consequential.

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POSTECH team turns the ribosome into a six-input logic gate, expanding what living cells can compute - The Monexus